Compartment Syndrome

Original Editor - Racheal Lowe Top Contributors - Alex Palmer, Lucinda hampton, Jessie Tourwe, Rachael Lowe, Kim Jackson, Manisha Shrestha, Admin, Uchechukwu Chukwuemeka, Wanda van Niekerk and Karen Wilson




Introduction

Acute Compartment Syndrome is a condition in which there is increased pressure within a closed osteofascial compartment, resulting in impaired local circulation. Without prompt treatment, acute compartment syndrome can lead to ischemia and eventually, necrosis.

The anterior compartment of the leg is the most common location for compartment syndrome. Other locations in which acute compartment syndrome is seen include the forearm, thigh, buttock, shoulder, hand, and foot.

See Compartment Syndrome of the Lower Leg; Compartment Syndrome of the Forearm; Compartment Syndrome of the Foot.

Etiology

Acute compartment syndrome can occur without any precipitating trauma but typically occurs after a long bone fracture, with tibial fractures being the most common cause of the condition, followed by distal radius fractures.

• Seventy-five percent of cases of acute compartment syndrome are associated with fractures. After fractures, the most common cause of acute compartment syndrome is soft tissue injuries.
• Other causes of acute compartment syndrome include burns, vascular injuries, crush injuries, drug overdoses, reperfusion injuries, thrombosis, bleeding disorders, infections, improperly placed casts or splints, tight circumferential bandages, penetrating trauma, intense athletic activity, and poor positioning during surgery.
• In children, supracondylar fractures of the humerus and both ulnar and radial forearm fractures are associated with compartment syndrome.

Epidemiology

The incidence of acute compartment syndrome is estimated to be 7.3 per 100,000 in males and 0.7 per 100,000 in females, with the majority of cases occurring after trauma. Tibial shaft fracture is the most common cause of acute compartment syndrome (associated with a 1 to 10 percent incidence of acute compartment syndrome).

Mechanism of Injury / Pathological Process

The connective tissue forming a compartment is not pliable, so when bleeding or swelling occurs within the compartment, the intra-compartmental pressure rises.

Normally a non-contracting muscle contains a pressure near zero.

• If the pressure rises up to 30 mmHg, the vessels will be compressed, resulting in pain and a decrease in blood flow.
• Lymphatic drainage will activate to prevent increasing interstitial fluid pressure.
• Once the effects of lymphatic drainage have reached their maximum, the pressure within the compartments will cause physiological defects, such as a nerve dysfunction and deformation.

• Haemorrhage or oedema causes the interstitial pressures within the soft tissues to increase, creating possible ischemia by loss of capillary refill.
• When a body part is not provided with blood for more than eight hours, the damage is irreversible and may lead to the death of the concerning tissues.

Clinical Presentation

Symptoms of Chronic Compartment Syndrome

Obtaining an accurate patient history is vital, due to the objective examination often not showing much of note. In a typical case, the patient will present with pain in a compartment of the leg, at the same time, distance and intensity of exercise. The pain shall continue to increase until it becomes unbearable and the patient stops exercising, causing the pain to subside with rest.

• Pain on palpation of involved muscles
• Pain with passive stretching of muscles
• The feeling of firmness of involved compartments
• Muscle herniation can be palpated in 40-60% of patients with compartment syndrome (Usually palpated over anterior tibia)
• Gait analysis may show excessive overpronation
• A neurological exam may show weakness and numbness of the affected compartment
  

Remember the 5 P’s: Pain, Pallor, Paresthesia, Paralysis, Pulselessness

Prognosis

The prognosis after treatment of compartment syndrome depends mainly on how quickly the condition is diagnosed and treated. When fasciotomy is done within 6 hours, there is almost 100% recovery of limb function. After 6 hours, there may be residual nerve damage. Data show that when the fasciotomy is done within 12 hours, only two-thirds of patients have normal limb function. In very delayed cases, the limb may require an amputation.

Diagnostic Procedures

1. Intra-Compartmental Pressure Monitoring (ICP): Not required but can aid in diagnosis if uncertainty exists. Compartment pressures are often measured with a manometer, a device that detects intracompartmental pressure by measuring the resistance that is present when a saline solution is injected into the compartment. Another method employs a slit catheter, whereby a catheter is placed within the compartment, and the pressure measured with an arterial line transducer.
   
2. Less Invasive Measurement Techniques
   • Laser Doppler ultrasound
   • Methoxy isobutyl isonitrile enhanced magnetic resonance imaging (MRI)
   • Phosphate-nuclear magnetic resonance (NMR) spectroscopy

Outcome Measures

• Lower Extremity Functional Scale (LEFS)
• Foot and Ankle Ability Measure (FAAM)
• Visual Analogue Scale
• Patient Specific Functional Scale

For more see Outcome Measures Database

Management / Interventions

In the event of a diagnosis of Compartment syndrome (when there is a intra-compartment pressure of >30 mmHg) immediate surgical fasciotomy is needed to reduce the intracompartmental pressure.

Image 2: Compartment syndrome with fasciotomy procedure

• The ideal timeframe for fasciotomy is within six hours of injury
• Fasciotomy is not recommended after 36 hours following injury. When tissue pressure remains elevated for that amount of time, irreversible damage may occur, and fasciotomy may not be beneficial in this situation.

After a fasciotomy is performed and swelling dissipates, a skin graft is commonly used for incision closure. Patients must be closely monitored for complications which include infection, acute renal failure, and rhabdomyolysis.

If necrosis occurs before fasciotomy is performed, there is a high likelihood of infection which may require amputation. If infection occurs, debridement is necessary to prevent systemic spread or other complications.

Physiotherapy

Physiotherapy role in the treatment of the condition is vital, with or without surgical intervention. The physiotherapist may employ modalities that will improve range of motion, strength of the affected muscles, function and relief pain.

See highlighted links in Introduction for site specific Physiotherapy

Differential Diagnosis

These common pathologies may give the same pain characteristics or symptoms in the lower limbs:

• shin splints (medial tibial stress syndrome)
• stress fractures
• fascial defects
• peroneal nerve entrapment
• popliteal artery entrapment syndrome
• claudication